l General Information |
Product Name | Telmisartan |
General description | Telmisartan is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. |
Synonym | 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid; BIBR 277 |
Purity | ≥99.0%(HPLC) | CAS Number | 144701-48-4 |
Formula | C33H30N4O2 | Molecular Weight | 514.629 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or slightly yellowish solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
Ethanol | Very slightly soluble |
Water | Insolube |
l Biological Information |
Biochem/Physiol Actions | Telmisartan is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. |
Application | 1. Antihypertensive Agents 2. Angiotensin II Type 1 Receptor Blockers |
l Storage |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
