l General Information |
Product Name | CYC-116 |
General description | CYC116 is a potent inhibitor of Aurora A/B. |
Synonym | 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine; CYC 116; CYC116 |
Purity | ≥99.0%(HPLC) | CAS Number | 693228-63-6 |
Formula | C18H20N6OS | Molecular Weight | 368.46 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Off-white or light gray solid |
Solubility(25℃) | DMSO | ≥20mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | CYC116 is a potent inhibitor of Aurora A/B (Ki = 8.0 nM/9.2 nM), is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
