Product Name

Droxinostat

General description

Droxinostat is a selective inhibitor of HDAC.

Synonym

4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide; NS 41080; NS-41080; NS41080

Purity

≥96.0%(HPLC)

CAS Number

99873-43-5

Formula

C¹¹H¹⁴ClNO³

Molecular Weight

243.69

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥45mg/mL

Ethanol

≥45mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.

l  Packaging & Storage

Packaging

5mg; 10mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov