l General Information |
Product Name | Sapanisertib(INK-128) |
General description | Sapanisertib is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays. |
Synonym | 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine; MLN0128; INK 128 |
Purity | ≥99.0%(HPLC) | CAS Number | 1224844-38-5 |
Formula | C15H15N7O | Molecular Weight | 309.33 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Red solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Sapanisertib is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200 fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro invasion genes (vs Rapamycin). |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
