l General Information |
Product Name | VE-821 |
General description | VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki of 13 nM and IC50 of 26 nM in cell-free assay. |
Synonym | 3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide; VE 821; VE821 |
Purity | ≥99.0%(HPLC) | CAS Number | 1232410-49-9 |
Formula | C18H16N4O3S | Molecular Weight | 368.41 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Green solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki of 13 nM and IC50 of 26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ. |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
