l General Information |
Product Name | SCR7 |
General description | SCR7 is a specific DNA Ligase IV inhibitor. |
Synonym | 6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one; SCR7 Pyrazine |
Purity | ≥99.0%(HPLC) | CAS Number | 14892-97-8 |
Formula | C18H12N4OS | Molecular Weight | 332.38 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Light green solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ). SCR7 increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos. |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
