l General Information |
Product Name | LW6 |
General description | LW6 is a hypoxia-inducible factor 1(HIF) inhibitor. |
Synonym | methyl 3-[[2-[4-(1-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate; LW 6 |
Purity | ≥98.5%(HPLC) | CAS Number | 934593-90-5 |
Formula | C26H29NO5 | Molecular Weight | 435.51 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
Ethanol | Slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | LW6, a hypoxia-inducible factor 1(HIF) inhibitor, which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. It inhibits HIF and MDH2 with IC50 values of 4.4 and 6.3 μM, respectively. |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
