Product Name

Canertinib Dihydrochloride (CI-1033 HCl)

General description

Canertinib Dihydrochloride is a pan-ErbB inhibitor.

Synonym

N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide; dihydrochloride; CI 1033 HCl; CI1033 HCl;

Purity

≥98.5%(HPLC)

CAS Number

289499-45-2

Formula

C²⁴H²⁷Cl³FN⁵O³

Molecular Weight

558.86

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow solid

l  Biological Information

Biochem/Physiol   Actions

Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR (IC50 = 1.5 nM) and ErbB2(IC50 = 9.0 nM), no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4.

l  Packaging & Storage

Packaging

5mg; 10mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov