Product Name

Motesanib Diphosphate (AMG-706)

General description

Motesanib Diphosphate is a potent ATP-competitive inhibitor of VEGFR1/2/3, similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret.

Synonym

N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3carboxamide; phosphoric acid; AMG 706; AMG706

Purity

≥99.0%(HPLC)

CAS Number

857876-30-3

Formula

C²²H²³N⁵O·2H³PO⁴

Molecular Weight

569.44

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

≥15mg/mL

l  Biological Information

Biochem/Physiol   Actions

Motesanib Diphosphate is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, about 10-fold more selective for VEGFR than PDGFR and Ret.

l  Packaging & Storage

Packaging

5mg; 10mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov