l General Information |
Product Name | Losmapimod(GW-856553) |
General description | Losmapimod (GW-856553X) is a selective, potent, and orally active p38 MAPK inhibitor. |
Synonym | 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide; GW856553, GSK-AHAB |
Purity | ≥99.0%(HPLC) | CAS Number | 585543-15-3 |
Formula | C22H26FN3O2 | Molecular Weight | 383.46 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥40mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
