Product Name

Granisetron hydrochloride

General description

Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

Synonym

1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

Purity

≥99.0%(HPLC)

CAS Number

107007-99-8

Formula

C¹⁸H²⁴N⁴O · HCl

Molecular Weight

348.87

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Very slightly soluble

Ethanol

Very slightly soluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Granisetron Hydrochloride is the hydrochloride salt of an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

Application

1.     Antiemetics

2.     Serotonin Antagonists

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov