Product Name

Fosaprepitant Dimeglumine

General description

Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity.

Synonym

[5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-3-oxo-1H-1,2,4-triazol-2-yl]phosphonic acid; (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol; MK-0517

Purity

≥99.0%(HPLC)

CAS Number

265121-04-8

Formula

C³⁷H⁵⁶F⁷N⁶O¹⁶P

Molecular Weight

1004.844

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Very slightly soluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.

Application

1.     Antiemetics

2.     Neurokinin-1 Receptor Antagonists

l  Packaging & Storage

Packaging

25mg; 100mg; 250mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov