l General Information |
Product Name | Nabumetone |
General description | Nabumetone is a naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti inflammatory, antipyretic and analgesic activities. |
Synonym | 4-(6-Methoxy-2-naphthyl)-2-butanone |
Purity | ≥99.0%(HPLC) | CAS Number | 42924-53-8 |
Formula | C15H16O2 | Molecular Weight | 228.29 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or off-white solid |
Solubility(25℃) | DMSO | ≥40mg/mL |
Ethanol | ≥20mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Nabumetone is a naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti inflammatory, antipyretic and analgesic activities. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation. |
Application | Cyclooxygenase 2 Inhibitors |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
