l General Information |
Product Name | Tobramycin |
General description | Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. |
Synonym | O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine; NSC 180514 |
Purity | ≥98.5%(HPLC) | CAS Number | 32986-56-4 |
Formula | C18H37N5O9 | Molecular Weight | 467.52 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | Very slightly soluble |
Ethanol | Insoluble |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation. |
Application | Anti-Bacterial Agents |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
