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Amphotericin B

Product #: TL0670
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Details

l  General Information

Product Name

Amphotericin B

General description

Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity.

Synonym

(1S,3R,4E,6E,8E,10E,12E,14E,16E,18S,19R,20R,21S,25R,27R,30R,31R,33S,35R,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylic acid; NSC 527017; Fungizone

Purity

≥85.0%(HPLC)

CAS Number

1397-89-3

Formula

C47H73NO17

Molecular Weight

924.08

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow to orange solid

Solubility(25℃)

DMSO

≥20mg/mL

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

Application

1.     Antiprotozoal Agents

2.     Amebicides

3.     Anti-Bacterial Agents

4.     Antifungal Agents

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

-20

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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