l General Information |
Product Name | Netilmicin sulfate |
General description | Netilmicin Sulfate is an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. |
Synonym | (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; sulfuric acid; Certomycin; 1-N-Ethylsisomicin |
Purity | ≥98.0%(HPLC) | CAS Number | 56391-57-2 |
Formula | C42H92N10O34S5 | Molecular Weight | 1441.55 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Pale yellow or yellow solid |
Solubility(25℃) | DMSO | Very slightly soluble |
Ethanol | Insoluble |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | Netilmicin Sulfate is the sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational shift, thereby results in premature termination. This eventually leads to bacterial cell death. |
Application | 1. Protein Synthesis Inhibitors 2. Anti-Bacterial Agents |
l Packaging & Storage |
Packaging | 25mg; 100mg; 250mg; 1g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
