Product Name

Gadobutrol

General description

Gadobutrol is a gadolinium-based, hydrophilic, macrocyclic, electrically neutral contrast agent used in contrast-enhanced MRI (CE-MRI). Gadobutrol is a non-ionic, paramagnetic complex consisting of gadolinium (Gd₃₊) chelated with the macrocyclic compound dihydroxy-hydroxymethylpropyl tetraazacyclododecane-triacetic acid (butrol).

Synonym

2-[4,10-bis(carboxylatomethyl)-7-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetrazacyclododec-1 yl]acetate; gadolinium(3+); Gadovist; Gd-DO3A-butriol

Purity

≥99.0%(HPLC)

CAS Number

138071-82-6

Formula

C¹⁸H³¹GdN⁴O⁹

Molecular Weight

604.715

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

Ethanol

Practically insoluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Gadobutrol is a gadolinium-based, hydrophilic, macrocyclic, electrically neutral contrast agent used in contrast-enhanced MRI (CE-MRI). Gadobutrol is a non-ionic, paramagnetic complex consisting of gadolinium (Gd₃₊) chelated with the macrocyclic compound dihydroxy-hydroxymethylpropyl tetraazacyclododecane-triacetic acid (butrol). Following intravenous administration, gadobutrol may increase MRI sensitivity for the detection of tumors and inflammatory and demyelinating diseases of the central nervous system (CNS) that are associated with areas with blood-brain barrier defects due to altered perfusion or an enlarged extracellular space. This agent is eliminated in an unchanged form via the kidneys; extra-renal elimination is negligible.

Application

Contrast Media

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov