Product Name

Efavirenz

General description

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

Synonym

(4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; Sustiva, Stocrin, DMP-266, DMP 266

Purity

≥98.0%(HPLC)

CAS Number

154598-52-4

Formula

C¹⁴H⁹ClF³NO²

Molecular Weight

315.67

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.

Application

1.     Cytochrome P-450 CYP3A Inducers

2.     Cytochrome P-450 CYP2C9 Inhibitors

3.     Cytochrome P-450 CYP2B6 Inducers

4.     Cytochrome P-450 CYP2C19 Inhibitors

5.     Reverse Transcriptase Inhibitors

l  Packaging & Storage

Packaging

25mg; 100mg; 250mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov