Product Name

Diphenhydramine hydrochloride

General description

Diphenhydramine hydrochloride is a histamine H1 antagonist.

Synonym

2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride; Diphenhydramine HCl

Purity

≥99.0%(HPLC)

CAS Number

147-24-0

Formula

C¹⁷H²²ClNO

Molecular Weight

291.82

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Diphenhydramine Hydrochloride is the hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

Application

1.     Sleep Aids, Pharmaceutical

2.     Anesthetics, Local

3.     Histamine H1 Antagonists

4.     Anti-Allergic Agents

5.     Antiemetics

6.     Hypnotics and Sedatives

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov