l General Information |
Product Name | Zoledronic Acid |
General description | Zoledronic acid is a potent osteoclast inhibitor. |
Synonym | (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid; Zoledronate; CGP 42446 |
Purity | ≥98.0%(HPLC) | CAS Number | 118072-93-8 |
Formula | C5H10N2O7P2 | Molecular Weight | 272.09 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | Very slightly soluble |
Ethanol | ≥35mg/mL (0.1M NaOH (aq) ) |
Water | ≥25mg/mL |
l Biological Information |
Biochem/Physiol Actions | Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix. |
Application | Bone Density Conservation Agents |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
