Product Name

Amiodarone Hydrochloride

General description

Amiodarone Hydrochloride is the hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities.

Synonym

(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride; Amiodarone HCL

Purity

≥99.0%(HPLC)

CAS Number

19774-82-4

Formula

C25H30ClI2NO3

Molecular Weight

681.778

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥20mg/mL

Ethanol

≥10mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Amiodarone Hydrochloride is the hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.

Application

1.     Anti-Arrhythmia Agents

2.     Cytochrome P-450 CYP3A Inhibitors

3.     Cytochrome P-450 CYP2C9 Inhibitors

4.     Cytochrome P-450 CYP1A2 Inhibitors

5.     Sodium Channel Blockers

6.     Vasodilator Agents

7.     Cytochrome P-450 CYP2D6 Inhibitors

8.     Potassium Channel Blockers

l  Packaging & Storage

Packaging

1g; 5g

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov