Phone:| Tech Support:| E-mail:

Tiopronin

Product #: TL0597
Image SKU-Pack Size Stock Price($) Quantity

Documents

Details

l  General Information

Product Name

Tiopronin

General description

Tiopronin is a prescription thiol drug used primarily in the treatment of severe homozygous cystinuria.

Synonym

2-(2-sulfanylpropanoylamino)acetic acid; N-(2-Mercaptopropionyl)glycine

Purity

≥98.0%(HPLC)

CAS Number

1953-02-2

Formula

C5H9NO3S

Molecular Weight

163.19

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥30mg/mL

Ethanol

≥30mg/mL

Water

≥30mg/mL

l  Biological Information

Biochem/Physiol   Actions

Tiopronin is an acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

Kidney stones form when the solubility limit is exceeded and urine becomes supersaturated with endogenous cystine. Tiopronin is an active reducing agent which undergoes a thiol-disulfide exchange with cystine to form a water-soluble mixed disulfide complex. Thus, the amount of sparingly soluble cystine is reduced. By reducing urinary cystine concentrations below the solubility limit, tiopronin helps reduce cystine stone formation.

l  Packaging & Storage

Packaging

50mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


天问科技