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Mifepristone

Product #: TL0584
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Details

l  General Information

Product Name

Mifepristone

General description

Mifepristone is a progestational and glucocorticoid hormone antagonist.

Synonym

1β-(4-Dimethyl­amino)­phenyl-17β-hydroxy-17-(1-propynyl)­estra-4,9-dien-3-one; RU-38486, RU-486

Purity

≥99.0%(HPLC)

CAS Number

84371-65-3

Formula

C29H35NO2

Molecular Weight

429.59

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Pale yellow or yellow solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥15mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Mifepristone is a derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities.

Application

1.    Contraceptives, Oral, Synthetic

Oral contraceptives which owe their effectiveness to synthetic preparations.

2.    Contraceptives, Postcoital, Synthetic

Postcoital contraceptives which owe their effectiveness to synthetic preparations.

3.    Luteolytic Agents

Chemical compounds causing LUTEOLYSIS or degeneration.

4.    Menstruation-Inducing Agents

Chemical compounds that induce menstruation either through direct action on the reproductive organs or through indirect action by relieving another condition of which amenorrhea is a secondary result.

5.    Abortifacient Agents, Steroidal

Steroidal compounds with abortifacient activity.

6.    Hormone Antagonists

Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.

l  Packaging & Storage

Packaging

250mg; 1g; 5g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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