Product Name

(±)-Ajmaline

General description

(±)-Ajmaline is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.

Synonym

Ajmalin; Cartagine; Ajmalin; Rytmalin;

Purity

≥95.0%(HPLC)

CAS Number

4360-12-7

Formula

C²⁰H²⁶N²O²

Molecular Weight

326.439

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥15mg/mL

Ethanol

Sparingly soluble

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Ajmaline is a class 1A antiarrhythmic agent. By interfering with the sodium channels, this drug allows for improvement in abnormal rhythms of the heart.

The class I antiarrhythmic agents interfere with the sodium channel. A class IA agent lengthens the action potential (right shift) which brings about improvement in abnormal heart rhythms. This drug in particular has a high affinity for the Nav 1.5 sodium channel.

Application

1.    Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

2.    Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.

l  Packaging & Storage

Packaging

10mg; 25mg

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov