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Clonidine Hydrochloride

Product #: TL0555
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Details

l  General Information

Product Name

Clonidine Hydrochloride

General description

Clonidine Hydrochloride is an imidazoline   derivate and centrally-acting alpha-adrenergic agonist as well as antagonist with antihypertensive activity.

Synonym

2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride; Clonidine HCl

Purity

≥99.0%(HPLC)

CAS Number

4205-91-8

Formula

C9H10Cl3N3

Molecular Weight

266.55

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Clonidine Hydrochloride is the hydrochloride salt form of clonidine, an imidazoline derivate and centrally-acting alpha-adrenergic agonist as well as antagonist with antihypertensive activity. Clonidine hydrochloride binds to and stimulates central alpha-2 adrenergic receptors, thereby decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow, leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate.

Application

1.    Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

2.    Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS.

3.    Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals. Drugs that act in the central nervous system to reduce sympathetic activity are included here.

4.    Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.

l  Packaging & Storage

Packaging

1g; 5g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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