l General Information |
Product Name | Mafenide acetate |
General description | Mafenide acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase. |
Synonym | 4-Aminomethylbenzenesulfonamide acetate salt, 4-Homosulfanilamide, Mafenide, Marfanil |
Purity | ≥99.0%(HPLC) | CAS Number | 13009-99-9 |
Formula | C9H14N2O4S | Molecular Weight | 246.28 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥45mg/mL |
Ethanol | Slightly soluble |
Water | ≥45mg/mL |
l Biological Information |
Biochem/Physiol Actions | Mafenide Acetate is the acetate salt form of mafenide, a synthetic sulfonamide analog of para aminobenzoic acid (PABA) with topical anti-infective activity. Mafenide acetate competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, thereby interferes with normal folic acid metabolism. As a result, de novo synthesis of pyrimidines, which requires folate metabolites, is impeded and subsequently DNA synthesis is affected. Mafenide acetate is bacteriostatic against many gram-negative and gram positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes. |
Application | Anti-Infective Agents, Local Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
