l General Information |
Product Name | Bumetanide |
General description | Bumetanide is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. |
Synonym | 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid; Bumex |
Purity | ≥99.0%(HPLC) | CAS Number | 28395-03-1 |
Formula | C17H20N2O5S | Molecular Weight | 364.416 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥30mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Bumetanide is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. |
Application | 1. Diuretics Agents that promote the excretion of urine through their effects on kidney function. 2. Sodium Potassium Chloride Symporter Inhibitors |
l Packaging & Storage |
Packaging | 50mg; 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
