l General Information |
Product Name | Bosentan hydrate |
General description | Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. |
Synonym | 4-tert-Butyl-N-[6-(2-hydroxyethoxy)- 5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4 yl]benzenesulfonamide; Bosentan; Ro 47-0203 |
Purity | ≥97.0%(HPLC) | CAS Number | 157212-55-0 |
Formula | C27H31N5O7S | Molecular Weight | 569.63 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. |
Application | 1. Endothelin Receptor Antagonists Compounds and drugs that bind to and inhibit or block the activation of endothelin rececptors. 2. Antihypertensive Agents Drugs used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics. |
l Packaging & Storage |
Packaging | 50mg |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
