l General Information |
Product Name | Mevastatin |
General description | Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. |
Synonym | [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; ML-236B; Compactin |
Purity | ≥98.0%(HPLC) | CAS Number | 73573-88-3 |
Formula | C23H34O5 | Molecular Weight | 390.51 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Very slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. Mevastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG CoA reductase. Mevastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with 10,000 times greater affinity than its natural substrate. The bicyclic portion of mevastatin binds to the coenzyme A portion of the active site. |
Application | 1. Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. 2. Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. 3. Hydroxymethylglutaryl-CoA Reductase Inhibitors Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis. 4. Anticholesteremic Agents Substances used to lower plasma cholesterol levels. |
l Packaging & Storage |
Packaging | 250mg; 1g; 5g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
