Product Name

Omeprazole Sodium hydrate

General description

Omeprazole Sodium is a selective and irreversible proton pump inhibitor.

Synonym

sodium; 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide; hydrate; Omeprazole sodium

Purity

≥98.0%(HPLC)

CAS Number

95510-70-6

Formula

C¹⁷H¹⁹N³NaO³S

Molecular Weight

368.41

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or almost white solid

Solubility(25℃)

DMSO

≥25mg/mL

Ethanol

≥10mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Omeprazole Sodium is the sodium salt form of a benzimidazole with selective and irreversible proton pump inhibitor activity. In the acidic compartment of parietal cells, omeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H₊/K₊ ATPase), thereby inhibiting its activity and the parietal cell secretion of H₊ ions into the gastric lumen, the final step in gastric acid production. H₊/K₊ ATPase is an integral membrane protein of the gastric parietal cell.

Application

1.    Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-Exchanging ATPase. They are used as anti-ulcer agents and sometimes in place of histamine H2 antagonists for gastroesophageal reflux.

2.    Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. This has included antibiotics to treat helicobacter infections; Histamine H2 antagonists to reduce gastric acid secretion; and antacids for symptomatic relief.

l  Packaging & Storage

Packaging

250mg; 1g; 5g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov