l General Information |
Product Name | Methazolamide |
General description | Methazolamide is a sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. |
Synonym | N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide; CL 8490 |
Purity | ≥99.0%(HPLC) | CAS Number | 554-57-4 |
Formula | C5H8N4O3S2 | Molecular Weight | 236.27 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥40mg/mL |
Ethanol | Slightly soluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol Actions | Methazolamide is a sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors. |
Application | 1. Carbonic Anhydrase Inhibitors A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of carbonic anhydrases. 2. Diuretics Agents that promote the excretion of urine through their effects on kidney function. |
l Packaging & Storage |
Packaging | 250mg; 1g; 5g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
