l General Information |
Product Name | Econazole nitrate |
General description | Econazole Nitrate is an imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties. |
Synonym | 1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole; NSC 243115 |
Purity | ≥99.0%(HPLC) | CAS Number | 24169-02-6 |
Formula | C18H16Cl3N3O4 | Molecular Weight | 444.70 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Slightly soluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol Actions | Econazole Nitrate is an imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties. Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components. In addition, econazole nitrate inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative enzyme activity which may contribute to cellular necrosis and cell death. Econazole nitrate is also active against some gram positive bacteria. This antifungal agent is used in the treatment various dermatomycoses. |
Application | 1. 14-alpha Demethylase Inhibitors Compounds that specifically inhibit STEROL 14-Demethylase. A variety of azole-derived antifungal agents act through this mechanism. 2. Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from fungicides, industrial because they defend against fungi present in human or animal tissues. |
l Packaging & Storage |
Packaging | 1g; 5g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
