Product Name

Allopurinol

General description

Allopurinol is a Xanthine Oxidase Inhibitor.

Synonym

1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one; 4-Hydroxypyrazolo(3,4-d)pyrimidine

Purity

≥98.0%(HPLC)

CAS Number

315-30-0

Formula

C⁵H⁴N⁴O

Molecular Weight

136.11

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or almost white solid

Solubility(25℃)

DMSO

≥25mg/mL

Ethanol

Very slightly soluble

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Allopurinol is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies.

Application

1.    Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

2.    Gout Suppressants

Agents that increase uric acid excretion by the kidney (uricosuric agents), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.

3.    Antimetabolites

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)

4.    Free Radical Scavengers

Substances that eliminate free radicals. Among other effects, they protect pancreatic islets against damage by cytokines and prevent myocardial and pulmonary reperfusion injury.

l  Packaging & Storage

Packaging

1g; 5g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov