Product Name

Pirfenidone

General description

Pirfenidone is an orally active synthetic antifibrotic agent structurally similar to pyridine 2,4 dicarboxylate.

Synonym

5-methyl-1-phenylpyridin-2-one; AMR-69; S-7701

Purity

≥99.0%(HPLC)

CAS Number

53179-13-8

Formula

C¹²H¹¹NO

Molecular Weight

185.225

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Off-White or Beige solid

Solubility(25℃)

DMSO

≥30mg/mL

Ethanol

≥30mg/mL

Water

Slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Pirfenidone is an orally active synthetic antifibrotic agent structurally similar to pyridine 2,4 dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis.

Application

1.    Analgesics

Compounds capable of relieving pain without the loss of consciousness.

2.    Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects

3.    Antineoplastic Agents

Substances that inhibit or prevent the proliferation of neoplasms.

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov