l General Information |
Product Name | Podophyllotoxin |
General description | Podophyllotoxin is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. |
Synonym | (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one; Podofilox |
Purity | ≥99.0%(HPLC) | CAS Number | 518-28-5 |
Formula | C22H22O8 | Molecular Weight | 414.41 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off-White solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
Ethanol | ≥10mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Podophyllotoxin is a pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. |
Application | 1. Tubulin Modulators Agents that interact with tubulin to inhibit or promote polymerization of microtubules. 2. Antineoplastic Agents, Phytogenic Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. 3. Keratolytic Agents Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases. |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
