Product Name

Alendronate sodium trihydrate

General description

Alendronate Sodium is a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity.

Synonym

sodium; (4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate; trihydrate; MK 217; G-704650

Purity

≥98.0%(HPLC)

CAS Number

121268-17-5

Formula

C⁴H¹⁸NNaO¹⁰P²

Molecular Weight

325.122

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or almost white solid

Solubility(25℃)

DMSO

Very slightly soluble

Ethanol

Very slightly soluble

Water

≥10mg/mL

l  Biological Information

Biochem/Physiol   Actions

Alendronate Sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.

Application

Bone Density Conservation Agents

Agents that inhibit bone resorption and/or favor bone mineralization and bone regeneration. They are used to heal bone fractures and to treat metabolic bone diseases such as osteoporosis.

l  Packaging & Storage

Packaging

1g; 5g

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov