l General Information |
Product Name | Chloroquine sulfate |
General description | Chloroquine Sulfate is the sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. |
Synonym | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;sulfuric acid |
Purity | ≥98.0%(HPLC) | CAS Number | 132-73-0 |
Formula | C18H28ClN3O4S | Molecular Weight | 417.949 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Faintly yellow solid |
Solubility(25℃) | DMSO | Slightly soluble |
Ethanol | Slightly soluble |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | Chloroquine Sulfate is the sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids. |
Application | 1. Antimalarials Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) 2. Amebicides Agents which are destructive to amebae, especially the parasitic species causing amebiasis in man and animal. 3. Antirheumatic Agents Drugs that are used to treat rheumatoid arthritis. |
l Packaging & Storage |
Packaging | 100mg; 250mg; 1g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
