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(L)-DON

Product #: TL0501
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Details

l  General Information

Product Name

(L)-DON

General description

6-Diazo-5-oxo-L-norleucine (DON) is a glutamine analogue.

Synonym

(Z,5S)-5-amino-1-diazonio-6-hydroxy-6-oxohex-1-en-2-olate; 6-Diazo-5-oxo-L-norleucine

Purity

≥95.0%(TLC)

CAS Number

157-03-9

Formula

C6H9N3O3

Molecular Weight

171.156

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or almost white solid

l  Biological Information

Biochem/Physiol   Actions

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase glutamine(amide)-2-oxoglutarate aminotransferase.

Application

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.

DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

l  Packaging & Storage

Packaging

5mg; 10mg; 25mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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