l General Information |
Product Name | (L)-DON |
General description | 6-Diazo-5-oxo-L-norleucine (DON) is a glutamine analogue. |
Synonym | (Z,5S)-5-amino-1-diazonio-6-hydroxy-6-oxohex-1-en-2-olate; 6-Diazo-5-oxo-L-norleucine |
Purity | ≥95.0%(TLC) | CAS Number | 157-03-9 |
Formula | C6H9N3O3 | Molecular Weight | 171.156 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
l Biological Information |
Biochem/Physiol Actions | 6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase glutamine(amide)-2-oxoglutarate aminotransferase. |
Application | 6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells. DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma. DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase. |
l Packaging & Storage |
Packaging | 5mg; 10mg; 25mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
