l General Information |
Product Name | Emtricitabine |
General description | Emtricitabine is a nucleoside analogue and reverse transcriptase inhibitor. |
Synonym | 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one |
Purity | ≥99.0%(HPLC) | CAS Number | 143491-57-0 |
Formula | C8H10FN3O3S | Molecular Weight | 247.25 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥45mg/mL |
Ethanol | ≥5mg/mL |
Water | ≥45mg/mL |
l Biological Information |
Biochem/Physiol Actions | Emtricitabine is a synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). |
l Packaging & Storage |
Packaging | 250mg; 1g; 5g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
