l General Information |
Product Name | Decitabine |
General description | Decitabine is a cytidine antimetabolite analogue with potential antineoplastic activity. |
Synonym | 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one; 2.5-aza-2' deoxycytidine |
Purity | ≥98.0%(HPLC) | CAS Number | 2353-33-5 |
Formula | C8H12N4O4 | Molecular Weight | 228.208 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
Ethanol | Very slightly soluble |
Water | ≥10mg/mL |
l Biological Information |
Biochem/Physiol Actions | Decitabine is a cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. |
Application | 1. Antimetabolites, Antineoplastic Antimetabolites that are useful in cancer chemotherapy. 2. Teratogens An agent that causes the production of physical defects in the developing embryo. 3. Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. |
l Packaging & Storage |
Packaging | 25mg; 100mg; 500mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
