l General Information |
Product Name | Pazopanib hydrochloride |
General description | Pazopanib hydrochloride is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. |
Synonym | 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2 methylbenzenesulfonamide;hydrochloride; GW 780604 |
Purity | ≥99.0%(HPLC) | CAS Number | 635702-64-6 |
Formula | C21H24ClN7O2S | Molecular Weight | 473.98 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥15mg/mL |
Ethanol | Very slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Pazopanib Hydrochloride is the hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
l Packaging & Storage |
Packaging | 10mg; 25mg; 100mg; 500mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
