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Dabrafenib

Product #: TL0492
Image SKU-Pack Size Stock Price($) Quantity
  • TL0492-10MG

    In stock

    99

    - +

    TL0492-25MG

    In stock

    156.4

    - +

    TL0492-100MG

    In stock

    414

    - +

    TL0492-500MG

    In stock

    1138.6

    - +

Documents

Details

l  General Information

Product Name

Dabrafenib

General description

Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity.

Synonym

N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6 difluorobenzenesulfonamide; GSK 2118436

Purity

≥99.0%(HPLC)

CAS Number

1195765-45-7

Formula

C23H20F3N5O2S2

Molecular Weight

519.56

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥25mg/mL

Ethanol

Very slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

Application

1.    Antineoplastic Agents

Substances that inhibit or prevent the proliferation of neoplasms.

2.    Protein Kinase Inhibitors

Agents that inhibit Protein Kinases.

l  Packaging & Storage

Packaging

10mg; 25mg; 100mg; 500mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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