l General Information |
Product Name | Apatinib mesylate |
General description | Apatinib mesylate is an orally bioavailable, selective VEGFR2 inhibitor. |
Synonym | N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3 carboxamide;methanesulfonic acid; Apatinib; YN968D1 |
Purity | ≥98.0%(HPLC) | CAS Number | 1218779-75-9 |
Formula | C25H27N5O4S | Molecular Weight | 493.582 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost white solid |
Solubility(25℃) | DMSO | ≥20mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. |
Application | 1. Antineoplastic Agents Substances that inhibit or prevent the proliferation of neoplasms. 2. Protein Kinase Inhibitors Agents that inhibit Protein Kinases. |
l Packaging & Storage |
Packaging | 10mg; 25mg; 100mg |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
