Product Name

Nicardipine Hydrochloride

General description

Nicardipine Hydrochloride is a potent calcium channel blockader with marked vasodilator action.

Synonym

5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride; RS-69216

Purity

≥99.0%(HPLC)

CAS Number

54527-84-3

Formula

C²⁶H³⁰ClN³O⁶

Molecular Weight

515.99

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Pale yellow to yellow solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Very  slightly soluble

Water

Very  slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.

Application

1. Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics.

2. Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

3. Vasodilator Agents

Drugs used to cause dilation of the blood vessels.

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov