l General Information |
Product Name | Gefitinib hydrochloride |
General description | Gefitinib hydrochloride is a selective tyrosine kinase receptor inhibitor. |
Synonym | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; hydrochloride; ZD-1839 hydrochloride |
Purity | ≥99.0%(HPLC) | CAS Number | 184475-55-6 |
Formula | C22H25Cl2FN4O3 | Molecular Weight | 483.365 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or light yellow solid |
Solubility(25℃) | DMSO | ≥5mg/mL |
Ethanol | Slightly soluble |
Water | Slightly soluble |
l Biological Information |
Biochem/Physiol Actions | Gefitinib is an anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. |
Application | 1. Antineoplastic Agents Substances that inhibit or prevent the proliferation of neoplasms. 2. Protein Kinase Inhibitors Agents that inhibit Protein Kinases. |
l Packaging & Storage |
Packaging | 10mg; 50mg; 200mg |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
