Product Name

Dasatinib hydrochloride

General description

Dasatinib hydrochloride is a pyrimidine and thiazole derived antineoplastic agent and protein kinase inhibitor of BCR-ABL kinase.

Synonym

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide; hydrochloride; BMS 354825 hydrochloride

Purity

≥99.0%(HPLC)

CAS Number

854001-07-3

Formula

C²²H²⁷Cl²N⁷O²S

Molecular Weight

524.465

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or light yellow solid

Solubility(25℃)

DMSO

≥25mg/mL

Ethanol

Slightly soluble

Water

≥25mg/mL(warmed)

l  Biological Information

Biochem/Physiol   Actions

Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or of the endogenous protein and by way of virally encoded kinase genes.

Application

1.    Antineoplastic Agents

Substances that inhibit or prevent the proliferation of neoplasms.

2.    Protein Kinase Inhibitors

Agents that inhibit protein kinases.

l  Packaging & Storage

Packaging

10mg; 50mg; 200mg

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov