Product Name

Flavopiridol Hydrochloride

General description

Flavopiridol Hydrochloride is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of cancer.

Synonym

NSC 649890 HCl; Alvocidib hydrochloride;

Purity

≥98.0%(HPLC)

CAS Number

131740-09-5

Formula

C²¹H²¹Cl²NO⁵

Molecular Weight

438.30

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Very   slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Alvocidib is the free base form of a   synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D , resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.

Application

1.    Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth.

2.    Antineoplastic Agents

Substances that inhibit or prevent the proliferation of neoplasms.

3.    Protein Kinase Inhibitors

Agents that inhibit Protein Kinases.

l  Packaging & Storage

Packaging

5mg; 25mg; 100mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov