l General Information |
Product Name | Flavopiridol |
General description | Flavopiridol is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of cancer. |
Synonym | 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one; Alvocidib; NSC 649890 HCl; HMR-1275 |
Purity | ≥98.0%(HPLC) | CAS Number | 146426-40-6 |
Formula | C21H20ClNO5 | Molecular Weight | 401.84 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
Ethanol | ≥5mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Alvocidib is the free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 , resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. |
Application | 1. Growth Inhibitors Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth. 2. Antineoplastic Agents Substances that inhibit or prevent the proliferation of neoplasms. 3. Protein Kinase Inhibitors Agents that inhibit Protein Kinases. |
l Packaging & Storage |
Packaging | 5mg; 25mg; 100mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
