Product Name

Irinotecan hydrochloride trihydrate

General description

Irinotecan, a prodrug, is converted to a biologically active metabolite SN-38 by a carboxylesterase converting enzyme.

Synonym

Irinotecan monohydrochloride trihydrate; Irinotecan HCl Trihydrate; CPT-11

Purity

≥99.0%(HPLC)

CAS Number

136572-09-3

Formula

C³³H⁴⁵ClN⁴O⁹

Molecular Weight

677.18

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Pale yellow to yellow solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Slightly soluble

Water

Slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Application

1.    Radiation-Sensitizing Agents

Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.

2.    Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

3.    Topoisomerase I Inhibitors

Compounds that inhibit the activity of DNA Topoisomerase I.

l  Packaging & Storage

Packaging

25mg; 100mg; 250mg; 1g

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov