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Naproxen Sodium

Product #: TL0470
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Details

l  General Information

Product Name

Naproxen Sodium

General description

Naproxen Sodium is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of naproxen is as a Cyclooxygenase Inhibitor.

Synonym

sodium;(2S)-2-(6-methoxynaphthalen-2-yl)propanoate; RS-3650

Purity

≥99.0%(HPLC)

CAS Number

26159-34-2

Formula

C14H13NaO3

Molecular Weight

252.245

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25℃)

DMSO

Slightly soluble

Ethanol

Insoluble

Water

≥45mg/mL

l  Biological Information

Biochem/Physiol   Actions

Naproxen Sodium is the sodium salt form of naproxen, a member of the arylacetic acid group of non-steroidal anti-inflammatory drugs (NSAIDs) with anti-inflammatory analgesic and antipyretic properties. Naproxen sodium reversibly and competitively inhibits cyclooxygenases (COX), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins. This inhibits the formation of prostaglandins that are involved in pain, inflammation and fever.

Application

1.    Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti inflammatory effects.

2.    Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

3.    Gout  Suppressants

Agents that increase uric acid excretion by the kidney, decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.

l  Packaging & Storage

Packaging

1g; 5g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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